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1

Regulation of HTLV-1 Tax Stability, Cellular Trafficking and NF-κB Activation by the Ubiquitin-Proteasome Pathway

Lavorgna, Alfonso, Harhaj, Edward

Journal:

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

2

Mechanisms of Oncogenesis by HTLV-1 Tax

Mohanty, Suchitra, Harhaj, Edward W.

Journal:

Year:

2020

File:

PDF, 1.98 MB

2020

3

Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells

Nicole S. Harhaj, Alistair J. Barber, David A. Antonetti

Journal:

Journal of Cellular Physiology

Year:

2002

Language:

english

File:

PDF, 989 KB

english, 2002

4

Regulation of inflammatory and antiviral signaling by A20

Kislay Parvatiyar, Edward W. Harhaj

Journal:

Microbes and Infection

Year:

2011

Language:

english

File:

PDF, 238 KB

english, 2011

5

Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin

David A. Antonetti, Ellen B. Wolpert, Lucas DeMaio, Nicole S. Harhaj, Russell C. Scaduto Jr

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 453 KB

english, 2002

6

The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax promotes persistent NF-κB activation by blocking the phosphorylation of the adaptor molecule TAX1BP

Noula Shembade, Edward W Harhaj

Journal:

Year:

2011

Language:

english

File:

PDF, 162 KB

english, 2011

7

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

Soratree Charoenthongtrakul, Qinjie Zhou, Noula Shembade, Nicole S Harhaj, Glen N Barber, Edward W Harhaj

Journal:

Year:

2011

Language:

english

File:

PDF, 162 KB

english, 2011

8

STAMBPL1 is a deubiquitinating enzyme that regulates HTLV-I Tax subcellular localization and NF-kB activation

Alfonso Lavorgna, Edward W Harhaj

Journal:

Year:

2011

Language:

english

File:

PDF, 163 KB

english, 2011

9

Deubiquitinases in the regulation of NF-κB signaling

Harhaj, Edward W, Dixit, Vishva M

Journal:

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

10

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

Shembade, Noula, Parvatiyar, Kislay, Harhaj, Nicole S, Harhaj, Edward W

Journal:

The EMBO Journal

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

11

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Shembade, Noula, Harhaj, Nicole S, Parvatiyar, Kislay, Copeland, Neal G, Jenkins, Nancy A, Matesic, Lydia E, Harhaj, Edward W

Journal:

Nature Immunology

Year:

2008

Language:

english

File:

PDF, 438 KB

english, 2008

12

Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling

Shembade, Noula, Harhaj, Nicole S, Liebl, Daniel J, Harhaj, Edward W

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 380 KB

english, 2007

13

Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation

Harhaj, Edward W, Good, LiFeng, Xiao, Gutian, Sun, Shao-Cong

Journal:

Year:

1999

Language:

english

File:

PDF, 310 KB

english, 1999

14

Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells

Sun, Shao-Cong, Maggirwar, Sanjay B, Harhaj, Edward W, Uhlik, Mark

Journal:

Year:

1999

Language:

english

File:

PDF, 332 KB

english, 1999

15

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

Harhaj, Edward W, Good, LiFeng, Xiao, Gutian, Uhlik, Mark, Cvijic, Mary Ellen, Rivera-Walsh, Isis, Sun, Shao-Cong

Journal:

Year:

2000

Language:

english

File:

PDF, 396 KB

english, 2000

16

Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis

Kate Barmak, Edward W. Harhaj, Brian Wigdahl

Journal:

Journal of NeuroVirology

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

17

Mechanisms of Persistent NF-κB Activation by HTLV-I Tax

Edward W. Harhaj, Nicole S. Harhaj

Journal:

Year:

2005

Language:

english

File:

PDF, 823 KB

english, 2005

18

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Shembade, Noula, Pujari, Rajeshree, Harhaj, Nicole S, Abbott, Derek W, Harhaj, Edward W

Journal:

Nature Immunology

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

19

Differential Effects of IκB Molecules on Tat-Mediated Transactivation of HIV-1 LTR

EDWARD HARHAJ, JOSEPH BLANEY, SCOTT MILLHOUSE, SHAO-CONG SUN

Journal:

Year:

1996

Language:

english

File:

PDF, 111 KB

english, 1996

20

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

MingFang Tao, Peter C. Scacheri, Jill M. Marinis, Edward W. Harhaj, Lydia E. Matesic, Derek W. Abbott

Journal:

Current Biology

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009

21

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway

Edward W. Harhaj, Nicole S. Harhaj, Christian Grant, Kate Mostoller, Timothy Alefantis, Shao-Cong Sun, Brian Wigdahl

Journal:

Year:

2005

Language:

english

File:

PDF, 717 KB

english, 2005

22

Deregulated expression of CD40 ligand in HTLV-I infection: Distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients

Nicole S. Harhaj, Branislava Janic, Juan C. Ramos, William J. Harrington Jr., Edward W. Harhaj

Journal:

Year:

2007

Language:

english

File:

PDF, 760 KB

english, 2007

23

Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration

Kate Barmak, Edward Harhaj, Christian Grant, Timothy Alefantis, Brian Wigdahl

Journal:

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

24

Regulation of NF-κB by deubiquitinases

Edward W. Harhaj, Vishva M. Dixit

Journal:

Immunological Reviews

Year:

2012

Language:

english

File:

PDF, 461 KB

english, 2012

25

Regulation of tight junctions and loss of barrier function in pathophysiology

Nicole S Harhaj, David A Antonetti

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2004

Language:

english

File:

PDF, 431 KB

english, 2004

26

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Masahito Kamanaka, Sean T. Kim, Yisong Y. Wan, Fayyaz S. Sutterwala, Maria Lara-Tejero, Jorge E. Galán, Ed Harhaj, Richard A. Flavell

Journal:

Year:

2006

Language:

english

File:

PDF, 1.23 MB

english, 2006

27

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

Gutian Xiao, Edward W Harhaj, Shao-Cong Sun

Journal:

Year:

2001

Language:

english

File:

PDF, 457 KB

english, 2001

28

IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation

Shembade, Noula, Harhaj, Edward W

Journal:

Cellular & Molecular Immunology

Year:

2011

Language:

english

File:

PDF, 162 KB

english, 2011

29

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Hutti, Jessica E., Porter, Melissa A., Cheely, Adam W., Cantley, Lewis C., Wang, Xiaodong, Kireev, Dmitri, Baldwin, Albert S., Janzen, William P., Harhaj, Edward

Journal:

Year:

2012

Language:

english

File:

PDF, 546 KB

english, 2012

30

Anti-CD70 Immunocytokines for Exploitation of Interferon-γ-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma

Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J., Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P., Balachandran, Siddharth, Harhaj, Edward

Journal:

Year:

2013

Language:

english

File:

PDF, 1.22 MB

english, 2013

31

HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF- B Activation and HTLV-1 Replication

Gao, L., Harhaj, E. W.

Journal:

Journal of Virology

Year:

2013

Language:

english

File:

PDF, 2.87 MB

english, 2013

32

Regulation of NF-κB signaling by the A20 deubiquitinase

Shembade, Noula, Harhaj, Edward W

Journal:

Cellular & Molecular Immunology

Year:

2012

Language:

english

File:

PDF, 2.02 MB

english, 2012

33

Regulation of Human T-Cell Leukemia Virus Type 1 Gene Expression by Sp1 and Sp3 Interaction with TRE-1 Repeat III

Yao, Jing, Grant, Christian, Harhaj, Edward, Nonnemacher, Michael, Alefantis, Timothy, Martin, Joel, Jain, Pooja, Wigdahl, Brian

Journal:

DNA and Cell Biology

Year:

2006

Language:

english

File:

PDF, 12.78 MB

english, 2006

34

Activation of I- κ B Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

Sun, Shao-Cong, Harhaj, Edward W., Xiao, Gutian, Good, LiFeng

Journal:

AIDS Research and Human Retroviruses

Year:

2000

Language:

english

File:

PDF, 303 KB

english, 2000

35

Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

Choi, Young Bong, Harhaj, Edward William

Journal:

Frontiers in Biology

Year:

2014

Language:

english

File:

PDF, 749 KB

english, 2014

36

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

Shembade, N., Ma, A., Harhaj, E. W.

Journal:

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

37

NF- B-inducing Kinase and I B Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF- B Activation

Uhlik, M., Good, L., Xiao, G., Harhaj, E. W., Zandi, E., Karin, M., Sun, S.-C.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 776 KB

english, 1998

38

Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways

Hyun, Jinhee, Ramos, Juan Carlos, Toomey, Ngoc, Balachandran, Siddharth, Lavorgna, Alfonso, Harhaj, Edward, Barber, Glen N., Ross, S. R.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 2.68 MB

english, 2015

39

EBV LMP1: New and shared pathways to NF- B activation

Lavorgna, A., Harhaj, E. W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 453 KB

english, 2012

40

IKK Serves as a Docking Subunit of the I B Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

Harhaj, E. W., Sun, S.-C.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 667 KB

english, 1999

41

ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling

Gao, L., Coope, H., Grant, S., Ma, A., Ley, S. C., Harhaj, E. W.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.22 MB

english, 2011

42

Secretion of the Human T Cell Leukemia Virus Type I Transactivator Protein Tax

Alefantis, T., Mostoller, K., Jain, P., Harhaj, E., Grant, C., Wigdahl, B.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.23 MB

english, 2005

43

Human T Cell Leukemia Virus Type 1 Tax Inhibits Innate Antiviral Signaling via NF- B-Dependent Induction of SOCS1

Charoenthongtrakul, S., Zhou, Q., Shembade, N., Harhaj, N. S., Harhaj, E. W.

Journal:

Journal of Virology

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

44

Activation of NF- B by Phosphatase Inhibitors Involves the Phosphorylation of I B at Phosphatase 2A-sensitive Sites

Sun, S.-C., Maggirwar, S. B., Harhaj, E.

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 7.94 MB

1995

45

Activation of NF- B by the Human T Cell Leukemia Virus Type I Tax Oncoprotein Is Associated with Ubiquitin-dependent Relocalization of I B Kinase

Harhaj, N. S., Sun, S.-C., Harhaj, E. W.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.58 MB

english, 2006

46

Constitutive Dephosphorylation and Activation of a Member of the Nuclear Factor of Activated T Cells, NF-AT1, in Tax-expressing and Type I Human T-cell Leukemia Virus-infected Human T Cells

Good, L., Maggirwar, S. B., Harhaj, E. W., Sun, S.-C.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 285 KB

english, 1997

47

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF- B Activation

Lavorgna, A., Harhaj, E. W.

Journal:

Journal of Virology

Year:

2012

File:

PDF, 54 KB

2012

48

Anchors Away for Ubiquitin Chains

Parvatiyar, K., Harhaj, E. W.

Journal:

Year:

2010

Language:

english

File:

PDF, 340 KB

english, 2010

49

Domain-specific Interaction with the I B Kinase (IKK) Regulatory Subunit IKK Is an Essential Step in Tax-mediated Activation of IKK

Xiao, G., Harhaj, E. W., Sun, S.-C.

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 839 KB

english, 2000

50

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF- B Activation

Lavorgna, A., Harhaj, E. W.

Journal:

Journal of Virology

Year:

2012

Language:

english

File:

PDF, 3.36 MB

english, 2012